Hmm, yeah I'd have to go with Batman Begins and then Superman (1978) if we're strictly speaking origins films, but for overall adaptations of comic books or graphic novels, then it's definitely Sin City followed by V for Vendetta for me.
I haven't seen Star Trek yet, so I can't say how that holds up as an "origins" film, but the fact that they have to yet again trot out Leonard Nimoy ticks me off. 
Anyhoo, I definitely have to go along with Casino Royale as being yet another great origins film (superhero or not). Thankfully they got got that one in before Bourne Again....err, I mean Quantum of Solace.
Brandon A. DuHamel
Big Picture Big Sound Writer/Blu-ray Reporter
Blu-ray & DVD Forum Moderator
'"In a strange game
I saw myself as you knew me
When the change came,
And you had a
Chance to see through me
Though the other side is just the same
You can tell my dream is real
Because I love you, can you see me now."
- "On the Way Home," Neil Young